Jump to content


Photo

Orexin/hypocretin Agonists?


  • Please log in to reply
46 replies to this topic

#41 IdiopathicHypersomniac

IdiopathicHypersomniac

    Member

  • Members
  • 899 posts

Posted 06 October 2013 - 02:04 PM

Go look at Jazz's recent profits.  Just Google it.  They're making a killing on Xyrem with all the price hikes.  The insurance companies are the ones who really should be complaining.  The drug is so difficult to get, it may as well not exist.

 

Doctors are reluctant to prescribe it, and insurance companies require that you do a few cartwheels to get it.  For example, my insurance company, Great-West Life, requires a full drop cataplexy, and the doctor must witness it.  In addition to that, all other drugs to treat cataplexy must have failed first.  Why?  Because the drug is so darn expensive.



#42 Ferret

Ferret

    Member

  • Members
  • 1,292 posts
  • Gender:Female

Posted 06 October 2013 - 04:57 PM

OK, I'm caving. They're capitalist pharma pigs at a feeding frenzy.

The increase in pricing monthly is unconscionable.

I had no idea that the price had increased that much until I read this...

http://forums.narcol...deal-for-xyrem/



#43 DeathRabbit

DeathRabbit

    Member

  • Members
  • 1,522 posts
  • Gender:Male
  • Location:Rocket City, USA
  • Interests:Music, video games, exercise, hookah, not feeling like crap

Posted 07 October 2013 - 09:15 AM

From what I understand, Jazz nearly went under a few years ago and started using price hikes on Xyrem as one of its ways to dig itself out of the hole. And then they were in danger of patent expiration in a few years, so they got a 5 year extension IRC by exchanging one of the hydrogen atoms with a deuterium, which slightly increases the half-life and bio-availibility they say. And maybe it does, but somehow, I doubt that was the motivating factor.



#44 Chippervan

Chippervan

    Member

  • Members
  • 38 posts
  • Gender:Male

Posted 07 October 2013 - 12:28 PM

I know this is stupid but say everyone gave up there medication for a few months and put it in a pot. Would that cover initial costs? I know i would be willing to do a lot to get a proper treatment. I just think, imagine you build a really good business model. So its not a donation as such, its more of an investment. This would require a lot and maybe it is impossible but maybe its worth a discussion. a positive brainstorming sesssion instead of a list of why it can't happen. and if you throw out a figure on drug development maybe base it on something specific (e.g. cost per/kg of synthesizing hypocretin, number of test subjects required, etc.). imagine in 10 years hypocretin comes out and all our receptors are gone. a study of mignot's in 2008 suggested this would not be the case, whoop whoop! but still nothings certain. the sooner hypocretin comes out the better



#45 Chippervan

Chippervan

    Member

  • Members
  • 38 posts
  • Gender:Male

Posted 10 October 2013 - 08:37 AM

My bad. Just saw the wakeupnarcolepsy website. 



#46 Ferret

Ferret

    Member

  • Members
  • 1,292 posts
  • Gender:Female

Posted 10 October 2013 - 10:59 AM

You're not bad, you're awesome. Thanks for the link

http://www.wakeupnarcolepsy.com

 

From that link I found the transcript of the recent FDA meeting and I will post it also where it was requested.

http://www.wakeupnar...-hearing-video/

 

It looks to be around 4 hours between the two links...think I'll have a nap in between :P



#47 eon

eon

    Member

  • Members
  • 10 posts

Posted 20 February 2015 - 09:44 AM

isn't Xyrem simply the sodium salt of the date rape drug GHB? 
 
Ask Bill Cosby where he gets his supply of GHB powders. We all could get it cheaper.  :)
 
While i'd prefer a natural source orexin agonist. I'm sure they exist, just haven't been found yet.
 
I'm not sure if GHB is patent-able since it existed long before it became prescription so I'm not sure why aren't other companies making generic versions. It could be due to narcolepsy being "rare" which means the market will be small which is why Xyrem is priced the way it is so the little market share "narcolepsy" drugs has will be worth pursing with a jacked up drug price.
 
Then again GHB has other indications (for depression, as an aphrodisiac, etc.)
 

Not as much as Xyrem!  Xyrem is paying thousands of dollars each month to flirt with death.  It costs $500 per bottle up here in Canada.  How many bottles are needed in a month in case I have to go that route?