I was diagnosed with N+C about 2 months ago. First doc I saw instantly put me on Nuvigil - and I had the headaches but they went away after about a week. I definitely felt more alert - but my cataplexy episodes still haunted me - almost daily and that was just something I had to address but couldn't find a doc to prescribe it - so I had to hunt around for the right one.
While still taking Nuvigil, I've had to alter the dose a little bit - some days more some days less. 250 split up am and lunch has been effective for me to keep awake and kill off my favorite afternoon 2pm nap. I cannot nap on Nuvigil - irregardless of how much I take it just keeps the mind going for me and I can't shut it off for naptime if I take a small dose or skip one of the split doses altogether. It does give me mild anxiety - something I've never experienced before - and I'm starting to get used to it.
Now that I'm on Xyrem 7.5g / night - I find that I don't need the full 250mg split up - I can ususally get to lunch on my coffee and then take 1/2 of a 250mg Nuvigil with food. That helps keep me alert and functionable until around 7 pm - where it's good to actually feel sleepy again. Unfortunately, my job hours are kinda goofy - and 7pm is too early and I really have to press hard to function until around 10pm when I get home. Then its the Xyrem dose and off to the land of nod. My biggest problem is trying to remember to eat - I've actually lost all my appetite and have to force myself to eat - when I should be hungry. Hard to know if that is a side-effect of either medicine. So, yes, Nuvigil is a positive medicine for me.