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Ral L-Carnitine

44 posts in this topic

An update: 

 

After some research, I determined that ALCAR would probably be better than the free form L-Carnitine. I have started using it for the last week and it seems to last longer and is more "focused" in my head and not my body. I am only at 1,000mg currently; will adjust as needed. 
 

Carnitine, specifically Acetyl-L-Carnitine (ALCAR), is being investigated for chronic fatigue syndrome as a biomarker of fatigue is alterations in the levels and distribution of ALCAR in the brain at rest; specifically the pre-frontal cortex.[207] This tends to be accompanied by a reduced uptake of ALCAR into the brain, which may precede the reduced neural levels of ALCAR.[208]

 

10.1. Fatigue in Healthy Humans and Animals

 

Supplementing ALCAR into the feed of animals increases ambulatory activity (defined as overall distance traveled) in both young and old rats, although the increase is typically much greater in older rats.[80][209]

In otherwise healthy humans, Acetyl-L-Carnitine at 2g (paired with another 2g of Propionyl-L-Carnitine) in older men was able to decrease fatigue while alleviating symptoms of 'andropause' (erectile dysfuntion).[205] Older individuals still (71-78) experience reductions in fatigue, as well as improvements in sleep disorders related to fatigue and reductions in post-exercise fatigue.[210]

 

10.2. Fatigue in other Disease States

 

It has been shown to decrease fatigue in a human population of hepatic encepalopathy, secondary to reducing ammonia levels which tend to induce fatigue,[211] reduce quality of life,[212] and hinder cognition.[213][214][215] As these benefits are seen by therapeutically reducing ammonia, they are unlikely to translate into other disease states. The connection of anti-fatigue is coincidental.

L-Carnitine supplementation has been shown to improve fatigue in persons with Celiac disease related fatigue, but requires adherence to a gluten-free diet prior to intervention to restore intestinal uptake of carnitine.[53] The mechanism of this improvement in fatigue is not known.

As an adjunct therapy for cancer, L-Carnitine may decrease fatigue indirectly through increased lean mass and reducing cancer cachexia.[36][216][217] Carnitine deficiency is prevalent among some forms of Cancer[35] and reversing this deficiency can theoretically reverse fatigue.[37] That being said, not all studies come back positive.[34] Doses tend to be around 2-3g daily of L-Carnitine or Acetyl-L-Carnitine.

Source: http://examine.com/supplements/L-Carnitine/

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What supplement brand are you using. I might give this a shot, but I want to make sure I don't get some inferior juju. These dang OTC supplements, absolutely 0 guarantee they are what they say they are, so since you seem to have found one that does something, I'd like to try that particular brand.

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I've been using liquid L-carnitine by dymatize on Amazon. I usually take it 30 mins prior to any workouts...it also helps burn belly fat :) I had been taking this prior to my N diagnosis, so maybe I need to up the dosage for fatigue! I really like the flavor and I can feel a slight energy boost just prior to my workout. Have you also tried Yohimbine HCL?? It has also helped some...still extremely sleepy. Supposed to start Nuvigil soon, but incredibly nervous about the side effects. I have hx of migraines and reallllly don't want to deal with a couple weeks worth. 

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Yes I have actually! I posted about it in the supplements thread. I find that Yohimbine HCL works for about two week --- then the effectiveness for me wears off. When it comes to stimulants, cycling them (and between them) has worked the best.

Nuvigil worked great for me. I am currently off of Nuvigil since my insurance sucks; but I plan to be back on it within a month or two. It works quite well. I did not notice any drop in effectiveness after a year of use; but I also took weekend "holidays" and started to cycle it after 6 months or so. 

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As you can tell from my sign in I am obviously a senior citizen since I have had narcolepsy for such a long time, so I do have other health problems, which appear to be more related to age than my narcolepsy.  I want to mention 2 of those health problems, because those are why I have started taking so many nutritional supplements including Acetyl L-Carnitine.  Before taking these supplements I had trouble keeping warm and kept my thermostat at an average of 76 degrees in the winter in addition to wearing layers of clothing.  I now keep my thermostat at an average of 72 degrees and I sometimes get too hot and shed some layers and turn the thermostat down to 71.  I also have peripheral neuropathy even though I am not diabetic and I also have a big problem with swelling in my feet, ankles and the lower part of my legs.  I began having problems with unusual fatigue in the last few years.  In order to address these problems I have been using B12, Alpha Limpoic Acid, and Vitamin E and my doctor recently prescribed Vitamin D for the fatigue so I take that also.  The Alpha Limpoic Acid and Vitamin E do miracles for the swelling and the B12 helped me not to be as cold all of the time.  Last winter I turned my thermostat down to 74.  Recently I added Co Q-10 and Acetyl L-Carnitine to the mix and now I keep the themostat at 72.  I just read about Acetyl L-Carnitine and narcolepsy.  I had no idea that it helps narcolepsy, but it is quite possible that it is also helping the narcolepsy.  My Alpha-Lipoic Acid Supplement has twice as much Acetyl-L Carnitine (400 mg) in it.  I have noticed that sometimes that supplement gave me some increased alertness and energy although the effect wasn't something immediate or anything.  I thought that it was from the Alpha-Lipoic Acid and I don't take it at night anymore, because it worked against my getting a good nights sleep.  I do take my Co Q-10 at night though and it has 200 mg of L-Carnitine and it doesn't keep me awake.  I really can't say for sure whether the L-Carnitine helps my narcolepsy or not, but I do know that since I increased the Alpha-Lipoic Acid and added Co Q-10, L-Carnitine and prescription Vitamin D to my regimen, I feel a whole lot better in many ways and have more energy.  Frankly I would recommend any and all of these vitamins for fatigue and alertness, except the Vitamin E.  The vitamin E helps with the swelling and that is all and I usually take it at night, because sometimes it actually makes me a little sleepy if I take it during the day when I am tired already.  I take Modafinil and an Antidepressant for my narcolepsy, but when I get really fatigued these medications barely work, even though they are normally pretty effective.  

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As DeathRabbit has stated, energy drinks have L carnitine in it. Its been shown to have effects on different things, like TSH I think was mentioned. I've been reading bits here and there, but I haven't really focused on it.

For the last two or three years, though, I've had 1-2 monsters a day. Normally, doctors would shout to stop, but thats because most people slam them, get the insane sugar/caffeine/niacin/whatever all at once, and crash horribly later, making their nervous system pull the Elvis Presley.

I have a 24 ounce can. Because I take 4 breaks, each break I pour 6oz with a tiny splash of mountain dew to sweeten it, and drink it. It provides a slow burning effect, rather than ingesting it all at once. When I don't get my vitamin Bs, L carnitine, and other ingredients, from whatever source, I feel it. I treat monster as a supplement. Limiting daily intake and monitoring caffeine. After doctors hear this, they generally agree its actually smart.

The key to supplementing with energy drinks, as opposed to multivitamins, is hydration. Caffeine helps me stay awake minimally, but still performs its diuretic duties. If I keep up with water, monster does great to keep a slow burning boost throughout a shift.

Its a unique little quirk, and I've tried other energy drinks, but monster is the only one that tastes decent enough to drink all the time. Luckily I have no teeth left to destroy. And my blood pressure, even with adderall, has never been better lol.

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Energy drinks put me to sleep

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ps: check out Vitacost for great prices on supplements.

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Energy drinks put me to sleep

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As DeathRabbit has stated, energy drinks have L carnitine in it. Its been shown to have effects on different things, like TSH I think was mentioned. I've been reading bits here and there, but I haven't really focused on it.

For the last two or three years, though, I've had 1-2 monsters a day. Normally, doctors would shout to stop, but thats because most people slam them, get the insane sugar/caffeine/niacin/whatever all at once, and crash horribly later, making their nervous system pull the Elvis Presley.

I have a 24 ounce can. Because I take 4 breaks, each break I pour 6oz with a tiny splash of mountain dew to sweeten it, and drink it. It provides a slow burning effect, rather than ingesting it all at once. When I don't get my vitamin Bs, L carnitine, and other ingredients, from whatever source, I feel it. I treat monster as a supplement. Limiting daily intake and monitoring caffeine. After doctors hear this, they generally agree its actually smart.

The key to supplementing with energy drinks, as opposed to multivitamins, is hydration. Caffeine helps me stay awake minimally, but still performs its diuretic duties. If I keep up with water, monster does great to keep a slow burning boost throughout a shift.

Its a unique little quirk, and I've tried other energy drinks, but monster is the only one that tastes decent enough to drink all the time. Luckily I have no teeth left to destroy. And my blood pressure, even with adderall, has never been better lol.

 

Hm, I also use to drink those low-cal Monster energy drinks. And I also use to prefer them to coffee. I did not even consider that they have some of the supplements I have added into my regular routine. 

I don't drink them every day (or weekly even) anymore since getting on a sustainable supplement and medication routine; but that does make sense to why they were so effective. 

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It is a balancing act, though. I can't drink too much, or I grow tolerant. Not enough hydration, and they're useless lol.

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I wonder if Emergen-C packets have the same goodies? I'm going to check into that!

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That is very interesting because my kids have a mitochondrial defect where they are prescribed levocarnitine (precription strength l-carnitine). This is a genetic condition caused by a recessive gene (im a carrier). The condition makes them at a higher risk for diabetes, hypoglycemia, liver and kidney issues. I wonder if there is some link to that gene and narcolepsy.

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Any updates from the people in this thread who were trying out carnitine (acetyl/non-acetyl)? Does it help in the short/long-term?

 

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Any updates from the people in this thread who were trying out carnitine (acetyl/non-acetyl)? Does it help in the short/long-term?

 

I've been taking it daily now since the start of this thread and it does help in the long term. Most of my complaints with Narcolepsy is the fatigue. Some days It wins, but most days now are highly manageable. 

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I've been taking it daily now since the start of this thread and it does help in the long term. Most of my complaints with Narcolepsy is the fatigue. Some days It wins, but most days now are highly manageable. 

That's good to hear. Thanks for letting me know. Do you take acetyl-l-carnitine or just l-carnitine (or fumarate)? I wonder if the non-acetyl form reaches the brain or not..

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That's good to hear. Thanks for letting me know. Do you take acetyl-l-carnitine or just l-carnitine (or fumarate)? I wonder if the non-acetyl form reaches the brain or not..

Acetyl. Definitely a difference. Also, some days I do forget to take it  --- its fine. As long as I am mostly consistent with it I've realized. 

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Acetyl is for cognitive function where non acetyl is for physical.  A lot of people use the non acetyl form before workouts.  Just got some acetyl myself to give a try!

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