Heidi L

Jazz Pharma Strikes New Deal For Xyrem

9 posts in this topic

Concert Pharma, Jazz Pharma Strike $120M Deal for Narcolepsy
 


The deal calls for the two companies to work together on a modified version
of sodium oxybate (Xyrem) for narcolepsy, a neurological disorder that
leads to excessive daytime sleepiness. Under the deal, Jazz will get the
worldwide commercial rights to Concert’s compounds that swap in deuterium
elements into sodium oxybate, including one dubbed C-10323 

 

Although the Concert drug hasn’t yet entered clinical trials, Jazz is hoping
it will provide a long line extension for its franchise drug sodium
oxybate, which was first FDA approved in 2002. The drug is cleared for narcolepsy
to reduce excess daytime sleepiness and reduce cataplexy (weak or paralyzed
muscles) attacks. Sales have been booming recently, up more than 60 percent, to
$102.6 million in the most recent quarter ended Sept. 30. The first patents on
the drug begin to expire in 2019 and 2020, according to the FDA Orange
Book. 



That's what I call thinking ahead.  They are paying 120 million dollars
to modify one hydrogen atom so they can get a new patent and keep charging you
an arm and a leg for a drug that doesn't even address the cause of your
illness.  They have no intention of ever distributing a generic
version.

 

Is this the type of spending on narcolepsy research you were hoping for?

Frankly, I think it's outrageous and unconscionable.



 

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Well it does look like they have improved the efficacy of the drug, which could lead to a lower dosage, with fewer side effects and maybe even shorten the fasting time before taking it. Or that might be a bunch of monkey poo they came up with to justify extending the patent life. I guess we'll find out soon enough. If it has marked improvement over Xyrem it could be a boon, but otherwise, It's just going to be a firther financial burden to us PWN. US patent law is pretty absurd sometimes. Swap hydrogen for hydrogen with an extra neutron and oh man, another 20 years on the patent!

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This was something I was afraid of... I was really hoping the patent would end so much sooner, so they would be forced to find a new/better drug.

 

I hope this will be an improvement but from what I know of pharmaceutical companies its just a ploy to make more money.  Sad but true.

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When I started taking Xyrem in 2005 the cost was $997.20. In December of 2012 it was $6999.60. This months bill was for $8122.80. I can't wate to see how mutch it is next month. I am so scard that it will hit a price that the insurance will not pay. I cant say that it helps the EDS, but i love living without the cataplexy. Well just a littel Cataplexy its not totaly gone.

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Yeah it's stupid expensive. I'm not anti capitalism actually, but patent law needs to be seriously reformed, and there needs to be a certain point at which an obscene profit margin becomes fraud.

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the funny part is I dont have the $3.10 to cover the co pay.

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I just ordered Xyrem for a 30 day free trial. I'll be receiving it on Saturday, hoping to post the reactions I might have. I'm really hoping this will be a miracle drug to lower the amount of medicine I take during the day! Anyone on Xyrem?

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It is a mircale drug!! Without it I have cataplexy about 40 times a day. With it 0 to 3 times. There are some side affects and storage issues. But they cant compare to the cataplexy being under control.

 

P.S. I dont take any day time meds.

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Most PWN have wonderful reactions to it. Others, like myself, not so much. I wont go into detail what happened to me, because sometimes side effects can be self-fulfilled. Just go into it with a positive attitude, but also realistic expectations. No drug will make you not have Narcolepsy at this point in time, so you will not be symptom free. But hopefully, it will be a tremendous aid in managing said symptoms!

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