Jump to content


Photo

Nuvigil Side Effects


  • Please log in to reply
17 replies to this topic

Poll: Which Nuvigil Side Effects Do You Have? (22 member(s) have cast votes)

Which Side Effects Do You Get When Taking Nuvigil?

  1. Jittery / Uneasiness (9 votes [18.75%] - View)

    Percentage of vote: 18.75%

  2. The Runs / Squirts (2 votes [4.17%] - View)

    Percentage of vote: 4.17%

  3. Drymouth (8 votes [16.67%] - View)

    Percentage of vote: 16.67%

  4. Voted Loss of Appetite (9 votes [18.75%] - View)

    Percentage of vote: 18.75%

  5. Spaciness (5 votes [10.42%] - View)

    Percentage of vote: 10.42%

  6. A Little Bit of All of Them (3 votes [6.25%] - View)

    Percentage of vote: 6.25%

  7. Other (11 votes [22.92%] - View)

    Percentage of vote: 22.92%

  8. None (1 votes [2.08%] - View)

    Percentage of vote: 2.08%

Vote Guests cannot vote

#1 austeenob

austeenob

    Member

  • Members
  • 41 posts
  • Gender:Male
  • Location:Powhatan, VA

Posted 19 May 2012 - 05:58 PM

i take 150mg. i try to take it every morning, just started recently. it seems to work. you sometimes feel jittery/uneasy at first. feels a little bit like a adhd medicine sometimes. but goes away eventually. but i usually take with alot of drink and food in the morning. i am awake more mentally then physcially, but sometime i can feel pretty good mentally and physcially. i can easily go from like 8am - 11pm with no nap on nuvigil. compared to taking like 1 or 2 30-60min naps everyday. some side effects i have had every day i have taking it are 1) the runs or squirts kinda... i go like 4 times i day with it because it makes me have to go more i think. 2) dry mouth, no matter how much many glasses of water i drink i still can feel the dry mouth. so start drinking a little at a time through out the day (i drink aobut 3 full tall glasses of water a day now) and still feel the bit of dry mouth. 3) maybe ocasionally i zone out when im on nuvigl for a bit. but as the day progress the jittery feeling goes away. 4) if you take it early enough to where 12 horus later is out of your system, it should help you sleep better as it does to me sometime. i workout on nuvigil and once you start working out you forget your even on medeicine. 6) uneasy jittery feeling sometimes. 7) concrete better i guess. couple other minor things.

For the most part, even though there a good amount of small side effects, i still think its worth it, compared to sleeping multiple times through out the day. just learn to manage the side effects, like if you get dry mouth from it, have a bottle of water with you and sip when ever you get the chance so you dont get slammed with dry mouth. But overall, for like an athlete/active person like me, i think it is very helpful. All though i do hear after a while it becomes less effective, so don't take it when you absoultely dont have to. and eventually you can just take a week or so break from it and come back and it will work like new. I havn't found any cataplexy diffrence i don't think. some days its worse then others (MILD CASE) when i dont think about it, sometimes i barely can tell or even forget i have it. so just learn your case. I DO want to try to add welbutrin (anti deprresent) for cataplexy 300mg xl to nuvigil. but im going to continue using this for now. good luck!!

#2 thepopespajamas

thepopespajamas

    Member

  • Members
  • 5 posts
  • Gender:Male
  • Location:Philadelphia, PA
  • Interests:Surfing, Rock Climbing, Biking, Reading and Guitar.

Posted 27 May 2012 - 11:27 AM

When I first was diagnosed with N, I was given Nuvigil 150mg to combat EDS. For a few days, it was like I was completely normal again. I was enjoying work, I could stay up without worrying about being exhausted the next day, and people noticed a positive change in my overall mood. However, it quickly began to wear off and I was upped to 240mg a day. I was on 240 for about 6 or 7 months until my last doctors visit. I honestly hate Nuvigil now. After the short honeymoon period, the side effects really began to suck: constant low-grade headache (I used to get migraines so I have not tolerance for any drug that makes my head hurt!), the spacey feeling that it gave me, the completely unreal memory degradation, and most of all the empty/hollow "my eyes are open but i'm so tired I want to die" kind of effect that it gave me. I told the doctor about this, so he switched me to Adderall 15mg IR twice a day. I just started it, but I have been on Adderall before and thought that it worked pretty well. I'm on Xyrem again as well, so hopefully this will be the ticket.

From what I have read, the overwhelming majority of people who have taken Nuvigil for EDS have not liked it. I'm sure it's somewhat due to the fact that those who don't like their medication are more likely to write about it, but there are very few positive reviews. I'm not saying that it wont work for anyone, but don't wait around for too long if you don't like the side effects. There are plenty of other proven medications for EDS that can be tried. I worry that the memory degradation will be a lasting side effect...

#3 The Dreamer

The Dreamer

    Member

  • Members
  • 107 posts
  • Gender:Male
  • Location:Manhattan, KS
  • Interests:Computers, Photography, Home Theatre Tech, Amateur Radio, Doctor Who, Volunteering, Engineering

Posted 30 May 2012 - 06:49 PM

Yeah, my biggest side effect from the Nuvigil was the headaches.... don't recall having headaches like this when I was Provigil.

Runs/Squirts....can't say it made a difference.... noticed my doc has IBS in my file, wonder if knowing would make any difference now.

Of course, I thought I'd feel better once I finally got a diagnosis....but I think I'm worse.

Perhaps I need to find a doc that'll treat the problem and not the symptoms....

The Dreamer.

#4 sweetsurrender

sweetsurrender

    Member

  • Members
  • 12 posts

Posted 04 June 2012 - 10:35 PM

I picked "other".

I am pretty sure it has had some effect on my blood. I have started to bruise incredibly easy and very quickly. Some bruises so big I could not even figure out what they were from, and days later when I figured it out I could not believe how huge the bruises were. My gums have started to bleed sometimes when I brush my teeth. And sometimes there is blood when I blow my nose.

I've gone to my pcd and had all kinds of blood tests done and they seem to be normal so he said it was okay to keep taking it, but I'm a little worried and going to bring it up when I see my sleep doctor next week.

Oh, and for a while I was unable to orgasm. :(

#5 Guest_tabster1_*

Guest_tabster1_*
  • Guests

Posted 22 June 2012 - 01:59 PM

I'm pretty sure nuvigil is interacting with my birth control pill. . .I've been having my period about every 2 weeks and it lasts for 10 days. It says on there that it could make your bcp ineffective but I thought it just meant in relation to pregnancy!

also, my appetite is gone. It's starting to come back a bit but I've lost weight since I've started taking Nuvigil. I can tell when it starts to wear off too because then I am STARVING and eat nonstop.

I had the headaches for the first few months, every day at the same time. It was like getting hit in the face with a brick they were that sudden. But I stuck it out and they eventually went away.

#6 Enginerd

Enginerd

    Member

  • Members
  • 109 posts
  • Gender:Not Telling

Posted 22 June 2012 - 11:27 PM

I worry that the memory degradation will be a lasting side effect...


Modafinil is actually being investigated as a cognitive enhancement drug, so it's strange to hear someone equate it to causing memory loss and/or cognitive dysfunction. I'm not doubting your experience; just making an observation! :blush:

Another observation: I noticed a few of you mentioned being started out on 150mg/day. When I was finally diagnosed with narcolepsy, my sleep specialist didn't hesitate to put me on the max dose immediately--250mg/day. She said I was evidently incredibly tired, and on follow-up visits, she wanted to prescribe additional stimulants to help me since I still appeared to struggle with staying awake. Now I'm wondering what the standard dosing is, and how it's determined since it sounds like there are varying degrees of narcolepsy, I suppose...although all of us just sound pretty freaking tired 24/7.

Although I wish I could "shop around" and try out a few other drugs before settling on modafinil, my heart arrhythmia precludes me from doing so...and apparently, modafinil is the safest stimulant since it wouldn't aggravate a cardiac arrhythmia much like methylphenidate.

I have definitely noticed different side-effects with Nuvigil vs. Provigil, and while I prefer Provigil when it comes to fewer side-effects, Nuvigil is much more effective in a sense that it's fast-acting, longer-acting, and makes me feel a bit more alert and high-strung.

#7 sweetsurrender

sweetsurrender

    Member

  • Members
  • 12 posts

Posted 24 June 2012 - 01:42 PM

Another observation: I noticed a few of you mentioned being started out on 150mg/day. When I was finally diagnosed with narcolepsy, my sleep specialist didn't hesitate to put me on the max dose immediately--250mg/day. She said I was evidently incredibly tired, and on follow-up visits, she wanted to prescribe additional stimulants to help me since I still appeared to struggle with staying awake. Now I'm wondering what the standard dosing is, and how it's determined since it sounds like there are varying degrees of narcolepsy, I suppose...although all of us just sound pretty freaking tired 24/7.


That is an interesting question. I wonder if it is just related to the particular doctor's attitude towards medication in general. The consensus in my area seems to be very conservative in every specialty I have had interaction with. So my doc started me on 150mg nuvigil, and at the follow up after I told her how it was working she upped it to 250mg. But she also wrote me a script for Adderall to take 'as needed'. I'm not sure the nuvigil is helping much, but she seems very hesitant to try anything else without giving nuvigil a through try.

#8 Guest_tabster1_*

Guest_tabster1_*
  • Guests

Posted 25 June 2012 - 05:31 PM

That is an interesting question. I wonder if it is just related to the particular doctor's attitude towards medication in general. The consensus in my area seems to be very conservative in every specialty I have had interaction with. So my doc started me on 150mg nuvigil, and at the follow up after I told her how it was working she upped it to 250mg. But she also wrote me a script for Adderall to take 'as needed'. I'm not sure the nuvigil is helping much, but she seems very hesitant to try anything else without giving nuvigil a through try.


Does it carry the same risk for dependence/abuse as ritalin etc? Maybe that's the reason.

#9 Enginerd

Enginerd

    Member

  • Members
  • 109 posts
  • Gender:Not Telling

Posted 26 June 2012 - 01:10 AM

Does it carry the same risk for dependence/abuse as ritalin etc? Maybe that's the reason.



It doesn't, which is why Nuvigil/Provigil are more loosely regulated as Schedule VI substances while Ritalin/Adderall are Schedule II and can only be prescribed monthly while (supposedly) under the strict care of a doctor. The only reason Modafinil is a scheduled drug at all is not because dependence was observed, but because of what little IS known about its mechanism of action. Because it indirectly affects dopamine pathways in the brain, the FDA felt there was the potential it could act like or be abused like amphetamines with some people, and it was better to be safe than sorry. It didn't help that it became a popular drug amongst college kids attempting to function better during the day or pull all-nighters.

My guess would be that doctors are trained to begin with lower doses then titrate to higher doses until the right one is found; I imagine this helps curb some of the potential side-effects, as well. But it just seemed like my sleep specialist had a mental scale of "fatigue" in her brain, factoring in both how I appeared during office visits and my sleep study results. But another girl with narcolepsy I know was started at 150mg also, eventually maxed out at 250mg, but that was way too much for her, and then she went to 175mg, I believe.

#10 needbetterlife

needbetterlife

    Member

  • Members
  • 15 posts

Posted 30 August 2013 - 10:58 PM

......

#11 nike0518

nike0518

    Member

  • Members
  • 43 posts
  • Gender:Male
  • Location:dallas, texas

Posted 02 September 2013 - 08:49 AM

i take in halves, one when i wake up (6:00) & one at 12.00p.m.no headaches if i take in halves . I take nuvigil 150mg & ritalin (generic) IR 20mg 3x/day.



#12 b.chrissie@yahoo.com

b.chrissie@yahoo.com

    Member

  • Members
  • 50 posts

Posted 12 September 2013 - 03:52 PM

Well, I started on 250 of Nuvigil per day which lasted for about four days. I quit taking it immediately because (I am a former drinker / smoker, quit 5 years ago) and all I wanted to do was smoke, drink and gamble...and I was ridiculously angry. This was right after diagnosis. I was switched to concerta which had absolutely no effect, positive or negative. Even after I doubled the dosage. I was then put back on Nuvigil at 50 once a day and now 50 twice a day. Today I had the realization that not only have I been sporadically smoking again :( but I have been super angry for no reason. Now I am completely devastated because I do not want to go thru the whole med transition again. Has anyone tried natural remedies? The doc said next on the list was the xyrem. I am opposed to this one for multiple reasons: 1-My boyfriend is a super light sleeper and it doesn't seem fair to wake him up every night. 2-The only reason I wake up in the morning is because HE hears my alarm, which is in another room. 2-From the research I have done, xyrem seems to work in the way I already sleep. I am out immediately when I lay down. The side effects listed seem to mirror exactly what I experience when I am not on meds...so why bother? And one of the side effects is bed wetting? My doc seems so adamant about it and I really don't want to try this one. Can anyone offer ANY advice? I feel like I am drowning in a sea of crazy



#13 b.chrissie@yahoo.com

b.chrissie@yahoo.com

    Member

  • Members
  • 50 posts

Posted 12 September 2013 - 03:56 PM

I forgot to mention that (as is evident by my counting in my previous post) I also cannot concentrate and have awful memory on the Nuvigil. Not like normal "oh I forgot" but like distant memories have been completely erased...I can't even grasp a tiny fraction of some memories.



#14 NetiNeti

NetiNeti

    Member

  • Members
  • 127 posts

Posted 13 September 2013 - 10:55 AM

The memory loss is interesting actually. I have found it to help, by clearing that "fog" we all usually have.

 

I posted this many times on this fourm, but my side effects were within the first month mainly (headaches, sensitivity to light). They were pretty bad, but stopped after about a month. Now I am just thirsty all of the time.

 

I am on 150mg. It works pretty well. A lot better then the methynedate I was on. I still have it "as needed". I sometimes use it on my off days (I take two of those a week). I've been on it for...10 months now. There has been some noticiable loss in effectiveness --- I do not feel "wired" or jittery when I first started taking it. 

 

Also, it does not last in my system for longer then the 15hr window now. When I first started it, it was actually hard to fall asleep at night. Now I can tell when it stops working and I just have to sleep.



#15 b.chrissie@yahoo.com

b.chrissie@yahoo.com

    Member

  • Members
  • 50 posts

Posted 16 September 2013 - 01:53 PM

That's what I read about it too, I am beyond dissappointed. It definitely made me more "foggy." I am on day three of vitamins and herbs...I haven't drifted off yet but I do have to say, I did not miss being this tired. But, I'd rather be tired than angry.



#16 doinmdirndest

doinmdirndest

    Member

  • Members
  • 357 posts
  • Gender:Male
  • Location:sf bay area, CA
  • Interests:Staying alive and wakeful, having fun doing it. Pursuit of the truth.

    Being w/the woman I love, and looking out for the both of us (and our little dog, too).

Posted 17 September 2013 - 06:56 AM

I inadvertently shoplifted twice on nuvigil. just went outside the store, at some point got the stunning realization that in my hand was merchandise I didn't pay for, went back in the store and paid. I do not steal,this never happened before or since.

major dehydration issue here, too. w/scabby lips.

#17 Potato

Potato

    Member

  • Members
  • 336 posts
  • Gender:Male
  • Location:Indiana, US
  • Interests:Chemistry, Medicine, Science, Computers, Traveling, Not Being Tired

Posted 22 September 2013 - 02:02 AM

That's what I read about it too, I am beyond dissappointed. It definitely made me more "foggy." I am on day three of vitamins and herbs...I haven't drifted off yet but I do have to say, I did not miss being this tired. But, I'd rather be tired than angry.

 

The "angry" feeling is usually the result of increased dopamine levels and is common with all drugs that increase dopamine including provigil, nuvigil, adderall, ritalin, etc. But at the same time you have to understand the anger isn't stemming from the drug itself. The drug is merely amplifying your natural emotional state. So where you might have been a little irritated, you are now extremely irritated. But it's not something that is limited to just anger. It can also have the same effect with positive emotions. You might find yourself being extremely sociable where normally you would only be slightly sociable. Or you might find yourself extremely happy where normally you would only be slightly happy. In the end you really have to make a pretty concerted effort to try to stay in a positive mood while on any drug that increases dopamine levels or you're going to have a bad time.

 

If you're feeling more fatigued or foggy after taking the drug, you should definitely start out at about a quarter of that dosage and slowly increase to the full amount. Usually headaches, fatigue, or brain fog is a result of simply overdoing it.

 

As far as natural remedies, sure, there are several things that might make an impact: 5-HTP before bed. Large amounts of inositol with every meal and before bed. Magnesium Glycinate at bedtime. Dextromethorphan before bed. (This one isn't really a natural remedy, but it is over-the-counter!) L-DOPA from Velvet Bean during the day. (May make you irritated similar to nuvigil/provigil.) Acetylcholine during the day. -- In the end you may find that one or more of these work to decrease sleepiness. But most likely your fatigue is so severe relative to the improvement that these and others might provide, that you'll still end up needing an actual pharmaceutical drug indicated for narcolepsy. I'm kind of like you in that I would really rather not use drugs if at all possible, but unfortunately narcolepsy is a real pain in the rear and we all have obligations. For instance I'm in an academic program that gives even healthy energetic people an extremely hard time, and in the end I just have to come to terms with the fact that the drugs available today may not be perfect but they're better than nothing.



#18 b.chrissie@yahoo.com

b.chrissie@yahoo.com

    Member

  • Members
  • 50 posts

Posted 22 September 2013 - 08:29 AM

Thanks Chemist! I really appreciate your feedback. Now that I look back at it, everything was intensified, not just the anger. I am already quite intense which is why I think it made me feel like I was going to burst. One of the biggest reasons I wanted to try to go natural (thank you for your suggestions on that as well) is because I am worried that there isn't a medicine out there that won't have the "angry effect" especialy since I am also on medication for anxiety disorder. After a week of natural remedies, I pretty much slept the entire day yesterday and was dragging all week. I think I am beginning to arrive at your same conclusion that something is better than nothing, I am just really dreading going through the roller coaster of finding the right med and then the right dose.