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Medline: Psychosis In The Context Of Sodium Oxybate Therapy.

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#1 Heidi L

Heidi L


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  • Interests:Narcolepsy Research. I have now been in remission for over five years and am going to make sure all of you will be too.

Posted 18 January 2012 - 10:36 AM

Psychosis in the context of sodium oxybate therapy.

Sodium oxybate (brand name Xyrem) is a sodium salt of gamma-hydroxybutyric acid (GHB), an endogenous CNS depressant, which is an effective treatment of narcolepsy. As a drug of abuse, GHB produces severe psychiatric side effects and withdrawal. However, there are no reports of these effects when using clinically recommended doses. This paper presents a case of a patient who developed altered mental status while taking the recommended dose of sodium oxybate and subsequently became psychotic upon abrupt discontinuation of the medication. It is important for prescribers of sodium oxybate to be aware of the possibility of significant psychiatric side effects of this medication, as well as withdrawal symptoms, even at clinical doses. CITATION: Langford J; Gross WL. Psychosis in the context of sodium oxybate therapy. J Clin Sleep Med 2011;7(6):665-666.