ericsgagnon

Where's My Hypocretin/orexin Nasal Spray?

37 posts in this topic

Wow...all of that is pretty fascinating. I'm actually quite close to a pharmacist who is in his fourth year of his doctor of pharmacy program and some of the things they do at his college involve compounding pharmaceuticals...I wonder if they might be able to do this...

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I have EDS and have been lurking this site for a while. I've been scouring the web for a cure or a way to reduce symptoms and it seems that Orexin A is the key to not masking the symptoms but resolving them.  But the problem is lack of demand / profit, right?  Well, it seems that with all the interest in nootropics, there is a market, and I may have uncovered a cheap source.

There is a website that sells 120 doses of Orexin A Nasal spray for 99.99 Euros. I'd give the name if it is appropriate, but I'm excited that for under $120 that there may be some relief for us either now or in the near future.

Description says: Each actuation delivers 50 mcg Orexin A into the nasal passages. Shake the bottle before use and apply two sprays into each nostril, preferably in the morning or when needed.

I'm curious what the group thinks.  Does this sound like a product that would work, and if so, might this type of offering be available in the US soon?

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They're pretty liberal here with the moderating aspects of the forum. Go ahead and provide the link to what you found and/or you could take one for the team and try it out. As with all meds, it may or may not work but there's only one way to find out.

May the force be with you!

 

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Normally I wouldn't post a link to a product, especially if I hadn't used it, but this really got my interest:

http://www.anthropologyreviews.com/product/orexin-a-nasal-spray/

I did my research on the site and nothing bad came up other than dispensing nootropics is a bit of a gray area.  I think this is the first time I've seen the prices for the nasal spray to be something reasonable that, if it worked, could be a solution for us.

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Like others I am seriously considering testing spray on my own. There is no hope for cure and at least 10 years for better medication.

so yes, we are kinda on our own on this decision/experiment but in most ways have been on my own in managing this 24/7 condition for the last 30 years.

Fear would be that it works but is so unaffordable. A good summary of research and treatment options was Stanford Centre for Narcolepsy med.stanford.ede/narcolepsy

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They only new treatment coming down the pike that I am aware of is a wakefulness-promoting medication by the makers of Xyrem. This was the most recent information I could find: http://www.sleepreviewmag.com/2016/06/jazz-pharmaceuticals-presents-new-data-human-abuse-liability-study-jzp-110/

On a more random note, has anyone tried Bulletproof coffee? It's supposed to work better than "regular" caffeine. Maybe it should go on my things-to-try list. 

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I'm not clear as to how bulletproof coffee could help promote wakefulness anymore than regular coffee, unless its in contrast to coffee with a ton of sweetener in it, which can cause a sugar crash. I prefer to pound loose leaf oolong and green teas all day. The caffeine isnt much more than a soda, but there's also a generous amount of Theanine, which helps stimulate without creating anxiety (or so the internet says). It seems to have helped, along with a bunch of the supplements I ordered for energy boosting.

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I've had the chance to personally try the orexin-a from "Ceretropic". I've had the best month of the last 7 years since using it, if only I can find some way to make it permanent. There's a few studies that show that intranasally and even IM does in fact cross the BBB. And because most of us have problems with prepro-orexin containing neurons and not the orexin receptors (OX1 & OX2) themselves, orexin-a does in fact activate them and give a feeling of "normalness". I've been using 200-300mcg myself. My next target is seeing if I can upregulate orexin producing neurons with nicotine patches (https://www.ncbi.nlm.nih.gov/pubmed/11014216) and seeing if there's a way to activate neurotensin, especially because I always feel ridiculously hot (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062391).

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2 hours ago, Pereise1 said:

I've had the chance to personally try the orexin-a from "Ceretropic". I've had the best month of the last 7 years since using it, if only I can find some way to make it permanent. There's a few studies that show that intranasally and even IM does in fact cross the BBB. And because most of us have problems with prepro-orexin containing neurons and not the orexin receptors (OX1 & OX2) themselves, orexin-a does in fact activate them and give a feeling of "normalness". I've been using 200-300mcg myself. My next target is seeing if I can upregulate orexin producing neurons with nicotine patches (https://www.ncbi.nlm.nih.gov/pubmed/11014216) and seeing if there's a way to activate neurotensin, especially because I always feel ridiculously hot (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062391).

Pereise1:

You seem to be the main source of user experience info for Ceretropic's Orexin-A nasal spray atm, so thank you for that!

Please try to update your experience with details of ongoing effectiveness over time, dosage, and time of administration of the Orexin-A nasal spray. Does it get you through most, or all, of the day feeling normal (oh, joy!)? Do you notice an effect on sleep quality? Please tell us what other meds you take, if you are comfortable with doing so. Do you have N with C or just N?

https://www.ceretropic.com/orexin-a

Re: nicotine

https://academic.oup.com/endo/article-lookup/doi/10.1210/endo.141.10.7707

I self-medicated with nicotine for 25-30 years. It didn't cure anything, but did help me complete my working years to the point I didn't even realize I had a sleep disorder. I did wonder why I needed naps whenever I ingested the drug after mid-day though! I had to quit the drug a couple of years ago, because, as with all (semi-)good things, it finally ceased to get the job done, naps or not. Lozenges may be an option. Be aware of its addictive property!

Orexin A loss - N with C vs. N only:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717206/

 

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1 hour ago, HBr said:

Pereise1:

You seem to be the main source of user experience info for Ceretropic's Orexin-A nasal spray atm, so thank you for that!

Please try to update your experience with details of ongoing effectiveness over time, dosage, and time of administration of the Orexin-A nasal spray. Does it get you through most, or all, of the day feeling normal (oh, joy!)? Do you notice an effect on sleep quality? Please tell us what other meds you take, if you are comfortable with doing so. Do you have N with C or just N?

https://www.ceretropic.com/orexin-a

Re: nicotine

https://academic.oup.com/endo/article-lookup/doi/10.1210/endo.141.10.7707

I self-medicated with nicotine for 25-30 years. It didn't cure anything, but did help me complete my working years to the point I didn't even realize I had a sleep disorder. I did wonder why I needed naps whenever I ingested the drug after mid-day though! I had to quit the drug a couple of years ago, because, as with all (semi-)good things, it finally ceased to get the job done, naps or not. Lozenges may be an option. Be aware of its addictive property!

Orexin A loss - N with C vs. N only:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717206/

 

No problem, I saw it come out a couple months ago and after waiting and waiting for user reports, I finally decided to bite the bullet and buy it for myself. I've also bought some from nootropic source which was cheaper but didn't come in an insulated sleeve, which is concerning. Still works either way, just doesn't feel as potent although I may have overdiluted it.

I can get through most of the day with it, especially after continued use. However, I take several other things that may confound the half life, possibly making it longer or shorter.

As for nicotine, I don't see myself getting addicted to it as, despite the boost in wakefulness, I rather hate the anxious feeling of it. I've barely started that experiment so I'll weigh perceivable long term benefits with it. And thanks for the studies, I've read both of those before and they sent me down a deep research rabbit hole.

I'll probably make another post with everything I've taken as I'd have to elaborate on the reasoning for some.

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