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Narcolepsy And The Machado Joseph'S Connection


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#1 ayesart

ayesart

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Posted 28 October 2009 - 03:02 PM

I was writing a very long article about DNA and Narcolepsy While switching back and forth to provide links from the internet I lost it all. I am stubborn so he we go again.

If you can recall I attempted to share information at the Jacksonville event during the presentation of the DNA study being done by the Stanford scientists. My timing was off because of time limitations that had been placed upon different segments of presentations and meetings.

I will attempt to present my thoughts on the matter again here to share with you today various things I have learned from my own research into the subject:

Let's begin with this interesting bit of information regarding the possible link between Narcolepsy and MJD.

Neuron. 2001 May;30(2):345-54.

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.
Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T.

Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss of orexin-containing neurons occurs in human patients with narcolepsy. We generated transgenic mice in which orexin-containing neurons are ablated by orexinergic-specific expression of a truncated Machado-Joseph disease gene product (ataxin-3) with an expanded polyglutamine stretch. These mice showed a phenotype strikingly similar to human narcolepsy, including behavioral arrests, premature entry into rapid eye movement (REM) sleep, poorly consolidated sleep patterns, and a late-onset obesity, despite eating less than nontransgenic littermates. These results provide evidence that orexin-containing neurons play important roles in regulating vigilance states and energy homeostasis. Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy.


URL link number 2:

http://en.wikipedia....-Joseph_disease

A possible cure for MJD and perhaps Narcolepsy Links to before and after Video's too.

http://richardsventu...ion-annual.html

Here is a URL link for professionals who understand the language of genetics:

http://www.ncbi.nlm....les/PMC2542958/

I am pressed for time now but I will return to coninue this little project of mine.